Ilaprazole sodium hydrate

Research use only, not for human use.

Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM.

Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor. Ilaprazole sodium hydrate irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium hydrate is used for the research of gastric ulcers. Ilaprazole sodium hydrate is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor.

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Animal Model:Male SD rat (after pylorus ligation)Dosage:3, 10, 30 mg/kg Administration:Intraduodenally Result:The acid output and volume significantly inhibited by about 60% and 46% at 3 mg/kg were s, respectively. At 30 mg/kg, it showed 93% and 73% inhibition on acid output and volume, respectively.

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Membrane Transporter/Ion Channel

Proton Pump

Proton pump

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2322264-11-7

424.45

C19H21N4NaO4S

>98% (HPLC)

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O=S(CC1=NC=CC(OC)=C1C)C2=NC3=C([N-]2)C=C(N4C=CC=C4)C=C3.[Na+].O.O

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(-20℃)

With Ice Pack

≥ 2 years